Strongly and repeatedly enriched in tumors, with mechanistic evidence that it promotes tumor growth and immune evasion.
Colorectal cancer
The toxin-producing form drives a pro-inflammatory, pro-tumor environment.
Strains carrying the pks island produce colibactin, a genotoxin that leaves a distinctive mutational signature in colorectal tumors.
Streptococcus gallolyticus is a long-recognized companion of colorectal cancer.
Protective butyrate producers tend to be depleted as tumors develop.
Reported in Disbiome, HMDAD (1 cited study).
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