High blood pressure Reduced
Some probiotic Lactobacillus strains modestly lower blood pressure in trials.
Preliminary
Bacteria · Genus
Lactobacillus
Associated with these conditions
Bacterial Vaginosis Reduced
Reported in Disbiome, HMDAD (1 cited study).
Moderate evidence
Type 2 diabetes Elevated
Reported in Disbiome, HMDAD (1 cited study).
Moderate evidence
Type 1 diabetes Reduced
Reported in Disbiome, HMDAD (1 cited study).
Moderate evidence
COPD Elevated
Reported in HMDAD (1 cited study).
Moderate evidence
Cystic fibrosis Elevated
Reported in HMDAD (1 cited study).
Moderate evidence
Liver cirrhosis Elevated
Reported in HMDAD (1 cited study).
Moderate evidence
Autism spectrum (ASD) Associated with
Reported in Disbiome.
Preliminary
Obesity Associated with
Reported in Disbiome.
Preliminary
Pouchitis Associated with
Reported in Disbiome.
Preliminary
Inflammatory bowel disease (IBD) Associated with
Reported in Disbiome, Peryton.
Moderate evidence
Parkinson’s disease Associated with
Reported in Disbiome.
Preliminary
Colorectal cancer Associated with
Reported in Disbiome.
Preliminary
Systemic sclerosis Associated with
Reported in Disbiome.
Preliminary
Irritable Bowel Syndrome Associated with
Reported in Disbiome, Peryton.
Moderate evidence
Autoimmune hepatitis Associated with
Reported in Disbiome.
Preliminary
Asthma Associated with
Reported in Disbiome.
Preliminary
Chronic Obstructive Pulmonary Disease Associated with
Reported in Disbiome.
Preliminary
Celiac Disease, Coaliac disease Associated with
Reported in Disbiome.
Preliminary
Interstitial cystitis Associated with
Reported in Disbiome.
Preliminary
Cutaneous burn Associated with
Reported in Disbiome.
Preliminary
Rectal Carcinoma Associated with
Reported in Disbiome.
Preliminary
Viral Diarrhea Associated with
Reported in Disbiome.
Preliminary
Polycystic Ovary Syndrome Associated with
Reported in Disbiome.
Preliminary
Transient Ischemic Attack Associated with
Reported in Disbiome.
Preliminary
Spinal cord injury Associated with
Reported in Disbiome.
Preliminary
Primary sclerosing cholangitis Associated with
Reported in Disbiome.
Preliminary
Postmenopausal Associated with
Reported in Disbiome.
Preliminary
Rheumatoid arthritis Associated with
Reported in Disbiome.
Preliminary
Eczema (atopic dermatitis) Associated with
Reported in Disbiome.
Preliminary
Chagas' disease Associated with
Reported in Disbiome.
Preliminary
Non-alcoholic fatty liver disease Associated with
Reported in Disbiome.
Preliminary
Infectious gastroenteritis Associated with
Reported in Disbiome.
Preliminary
Primary biliary cholangitis Associated with
Reported in Disbiome.
Preliminary
Hashimoto's thyroiditis Associated with
Reported in Disbiome.
Preliminary
Cirrhosis Associated with
Reported in Disbiome.
Preliminary
Caries Associated with
Reported in Disbiome.
Preliminary
Liver transplant Associated with
Reported in Disbiome.
Preliminary
Smoking Associated with
Reported in Disbiome.
Preliminary
Gestational diabetes Associated with
Reported in Disbiome.
Preliminary
Hyperthyroidism Associated with
Reported in Disbiome.
Preliminary
T2D with hypertension Associated with
Reported in Disbiome.
Preliminary
Short Bowel Syndrome Associated with
Reported in Disbiome.
Preliminary
Heart failure Associated with
Reported in Disbiome.
Preliminary
Alcoholic hepatitis Associated with
Reported in Disbiome.
Preliminary
Gastric carcinoma Associated with
Reported in Disbiome.
Preliminary
Hepatitis C Associated with
Reported in Disbiome.
Preliminary
Acquired Immunodeficiency Syndrome Associated with
Reported in Disbiome.
Preliminary
Protracted bacterial bronchitis Associated with
Reported in Disbiome.
Preliminary
Seminal hyperviscosity Associated with
Reported in Disbiome.
Preliminary
Oligoasthenoteratozoospermia Associated with
Reported in Disbiome.
Preliminary
Pancreatic cancer Associated with
Reported in Disbiome.
Preliminary
Infantile eczema Associated with
Reported in Disbiome.
Preliminary
Primary sclerosing cholangitis-IBD Associated with
Reported in Disbiome.
Preliminary
Schizophrenia Associated with
Reported in Disbiome.
Preliminary
Major depressive disorder Associated with
Reported in Disbiome.
Preliminary
Oral cancer Associated with
Reported in Disbiome.
Preliminary
Urgency urinary incontinence Associated with
Reported in Disbiome.
Preliminary
Pelvic inflammatory disease Associated with
Reported in Disbiome.
Preliminary
Overactive bladder Associated with
Reported in Disbiome.
Preliminary
Severe fever with thrombocytopenia syndrome Associated with
Reported in Disbiome.
Preliminary
Myasthenia gravis Associated with
Reported in Disbiome.
Preliminary
Graves' disease Associated with
Reported in Disbiome.
Preliminary
Hepatocellular cancer Associated with
Reported in Disbiome.
Preliminary
Sjögren Syndrome Associated with
Reported in Disbiome.
Preliminary
Coronary artery disease Associated with
Reported in Disbiome, Peryton.
Moderate evidence
Multiple sclerosis Associated with
Reported in Disbiome.
Preliminary
Cardiac valve calcification Associated with
Reported in Disbiome.
Preliminary
Urolithiasis Associated with
Reported in Disbiome.
Preliminary
Autism spectrum disorders Associated with
Reported in Disbiome.
Preliminary
Cervical intraneoplasia Associated with
Reported in Disbiome.
Preliminary
Influenza A Associated with
Reported in Disbiome.
Preliminary
Recurrent miscarriage Associated with
Reported in Disbiome.
Preliminary
HIV infection Associated with
Reported in Disbiome.
Preliminary
Thyroid carcinoma Associated with
Reported in Disbiome.
Preliminary
Urogenital Schistosomiasis Associated with
Reported in Disbiome.
Preliminary
Glycogen storage disease Associated with
Reported in Disbiome.
Preliminary
Food allergy Associated with
Reported in Disbiome.
Preliminary
Acne Associated with
Reported in Disbiome.
Preliminary
Bladder cancer Associated with
Reported in Disbiome.
Preliminary
Non alcoholic steatohepatitis Associated with
Reported in Disbiome.
Preliminary
Alzheimer’s disease Associated with
Reported in Disbiome.
Preliminary
Mucosa-associated lymphoid tissue lymphoma Associated with
Reported in Disbiome.
Preliminary
Colon polyps Associated with
Reported in Disbiome.
Preliminary
Eosinophilic esophagitis Associated with
Reported in Disbiome.
Preliminary
Chronic kidney disease Associated with
Reported in Disbiome.
Preliminary
Intrahepatic Cholangiocarcinoma Associated with
Reported in Disbiome.
Preliminary
Osteoporosis Associated with
Reported in Disbiome.
Preliminary
Multiple system atrophy Associated with
Reported in Disbiome.
Preliminary
Aerobic vaginitis Associated with
Reported in Disbiome.
Preliminary
Biliary atresia Associated with
Reported in Disbiome.
Preliminary
Attention Deficit Hyperactivity Disorder Associated with
Reported in Disbiome.
Preliminary
Iron-deficiency anaemia Associated with
Reported in Disbiome.
Preliminary
Psoriasis Associated with
Reported in Disbiome.
Preliminary
Miscarriage Associated with
Reported in Disbiome.
Preliminary
Chlamydia Associated with
Reported in Disbiome.
Preliminary
Pulmonary tubercolosis Associated with
Reported in Disbiome.
Preliminary
Kidney stone Associated with
Reported in Disbiome.
Preliminary
Aphthous ulcer Associated with
Reported in Disbiome.
Preliminary
Kidney stone with hypertension Associated with
Reported in Disbiome.
Preliminary
Stevens-Johnson syndrome Associated with
Reported in Disbiome.
Preliminary
Genitourinary lichen sclerosus Associated with
Reported in Disbiome.
Preliminary
Chronic urticaria Associated with
Reported in Disbiome.
Preliminary
Hepatitis B Associated with
Reported in Disbiome.
Preliminary
Invasive colorectal cancer Associated with
Reported in Disbiome.
Preliminary
Alcoholism Associated with
Reported in Disbiome.
Preliminary
Clostridium difficile infection Associated with
Reported in Disbiome.
Preliminary
Crohn Disease Associated with
Reported in Peryton.
Preliminary
Diarrhea Associated with
Reported in Peryton.
Preliminary
Celiac disease Associated with
Reported in Peryton.
Preliminary
Inflammatory Bowel Diseases Associated with
Reported in Peryton.
Preliminary
Parkinson Disease Associated with
Reported in Peryton.
Preliminary
Head and Neck Neoplasms Associated with
Reported in Peryton.
Preliminary
Colorectal Neoplasms Associated with
Reported in Peryton.
Preliminary
Breast Neoplasms Associated with
Reported in Peryton.
Preliminary
Rectal Neoplasms Associated with
Reported in Peryton.
Preliminary
Pancreatic Neoplasms Associated with
Reported in Peryton.
Preliminary
Liver Neoplasms Associated with
Reported in Peryton.
Preliminary
Stomach Neoplasms Associated with
Reported in Peryton.
Preliminary
Thyroid Neoplasms Associated with
Reported in Peryton.
Preliminary
Uterine Cervical Neoplasms Associated with
Reported in Peryton.
Preliminary
Alzheimer Disease Associated with
Reported in Peryton.
Preliminary
What shifts it
Chronic stress Lowers it
Mind & stress
Moderate evidence Well-established
Helps make
GABAneurotransmitter
The main inhibitory (calming) neurotransmitter — the same target as many anti-anxiety drugs. Certain bacteria make it via glutamate decarboxylase; Bifidobacterium adolescentis is a model producer, and its abundance correlates inversely with depression and anxiety.
Glutamateneurotransmitter
The brain’s primary excitatory neurotransmitter and the direct precursor to GABA. Many gut bacteria produce and interconvert it; the glutamate–GABA balance is a key lever the microbiome can nudge.
Acetylcholineneurotransmitter
Central to memory and every muscle contraction. Produced by strains including Lactobacillus plantarum; it also carries much of the vagus-nerve signalling that connects gut and brain.
Histamineneurotransmitter
Made by bacteria via histidine decarboxylase. It bridges immunity and the nervous system, and bacterial histamine production is central to histamine intolerance and gut inflammation.
Tyramineneurotransmitter
A trace amine bacteria make by decarboxylating tyrosine. It can raise blood pressure and is a classic dietary migraine trigger — a direct line from microbial metabolism to physiology.