Bacteria · Genus

Roseburia

Beneficial Butyrate-producing bacteria that help feed the gut lining and dampen inflammation.

Associated with these conditions

Cardiovascular disease Reduced

Depleted SCFA producers are reported in coronary disease cohorts.

Preliminary

Parkinson’s disease Reduced

Butyrate producers decline, consistent with the gut inflammation reported in Parkinson’s.

Moderate evidence

Type 1 diabetes Reduced

Reported in Disbiome, HMDAD (1 cited study).

Moderate evidence

Liver cirrhosis Reduced

Reported in HMDAD (1 cited study).

Moderate evidence

Multiple sclerosis Associated with

Reported in Disbiome.

Preliminary

Type 2 diabetes Associated with

Reported in Disbiome.

Preliminary

Pouchitis Associated with

Reported in Disbiome.

Preliminary

Inflammatory bowel disease (IBD) Associated with

Reported in Disbiome, Peryton.

Moderate evidence

Major depressive disorder Associated with

Reported in Disbiome.

Preliminary

Irritable Bowel Syndrome Associated with

Reported in Disbiome, Peryton.

Moderate evidence

Colorectal cancer Associated with

Reported in Disbiome.

Preliminary

HIV infection Associated with

Reported in Disbiome.

Preliminary

Cystic fibrosis Associated with

Reported in Disbiome.

Preliminary

High blood pressure Associated with

Reported in Disbiome, Peryton.

Moderate evidence

Spondyloarthritis Associated with

Reported in Disbiome.

Preliminary

Inactive Crohn's Disease Associated with

Reported in Disbiome.

Preliminary

Behcet's Disease Associated with

Reported in Disbiome.

Preliminary

Primary sclerosing cholangitis-IBD Associated with

Reported in Disbiome.

Preliminary

Chronic kidney disease Associated with

Reported in Disbiome.

Preliminary

Kawasaki disease Associated with

Reported in Disbiome.

Preliminary

Obesity Associated with

Reported in Disbiome.

Preliminary

Non alcoholic steatohepatitis Associated with

Reported in Disbiome.

Preliminary

Non-alcoholic fatty liver disease Associated with

Reported in Disbiome.

Preliminary

Hepatic encephalopathy Associated with

Reported in Disbiome.

Preliminary

Ankylosing spondylitis Associated with

Reported in Disbiome.

Preliminary

T2D with hypertension Associated with

Reported in Disbiome.

Preliminary

Short Bowel Syndrome Associated with

Reported in Disbiome.

Preliminary

Henoch-Schönlein Purpura Associated with

Reported in Disbiome.

Preliminary

Chronic alcoholic pancreatitis Associated with

Reported in Disbiome.

Preliminary

Hyperlipidemia Associated with

Reported in Disbiome.

Preliminary

Acquired Immunodeficiency Syndrome Associated with

Reported in Disbiome.

Preliminary

Reactive arthritis Associated with

Reported in Disbiome.

Preliminary

Infantile eczema Associated with

Reported in Disbiome.

Preliminary

Hashimoto's thyroiditis Associated with

Reported in Disbiome.

Preliminary

Anorexia Nervosa Associated with

Reported in Disbiome.

Preliminary

Autism spectrum (ASD) Associated with

Reported in Disbiome.

Preliminary

Maturity-onset diabetes of the young 2 Associated with

Reported in Disbiome.

Preliminary

Severe fever with thrombocytopenia syndrome Associated with

Reported in Disbiome.

Preliminary

Pulmonary tubercolosis Associated with

Reported in Disbiome.

Preliminary

Wilson's Disease Associated with

Reported in Disbiome.

Preliminary

Coronary artery disease Associated with

Reported in Disbiome, Peryton.

Moderate evidence

Keratitis Associated with

Reported in Disbiome.

Preliminary

Hand, foot and mouth disease Associated with

Reported in Disbiome.

Preliminary

Drug-resistant Epilepsy Associated with

Reported in Disbiome.

Preliminary

Anovulation Associated with

Reported in Disbiome.

Preliminary

Systemic lupus erythematosus Associated with

Reported in Disbiome.

Preliminary

Rheumatoid arthritis Associated with

Reported in Disbiome.

Preliminary

Cervical cancer Associated with

Reported in Disbiome.

Preliminary

Thyroid carcinoma Associated with

Reported in Disbiome.

Preliminary

Autism spectrum disorders Associated with

Reported in Disbiome.

Preliminary

Cholestasis Associated with

Reported in Disbiome.

Preliminary

Spinal cord injury Associated with

Reported in Disbiome.

Preliminary

Glycogen storage disease Associated with

Reported in Disbiome.

Preliminary

Chagas' disease Associated with

Reported in Disbiome.

Preliminary

Gastric carcinoma Associated with

Reported in Disbiome.

Preliminary

Food allergy Associated with

Reported in Disbiome.

Preliminary

Helicobacter pylori infection Associated with

Reported in Disbiome.

Preliminary

Asthma Associated with

Reported in Disbiome.

Preliminary

Bipolar disorder Associated with

Reported in Disbiome.

Preliminary

Atrial fibrillation Associated with

Reported in Disbiome.

Preliminary

Osteoporosis Associated with

Reported in Disbiome.

Preliminary

Fibromyalgia Associated with

Reported in Disbiome.

Preliminary

Uveitits Associated with

Reported in Disbiome.

Preliminary

Postmenopausal Associated with

Reported in Disbiome.

Preliminary

Posttraumatic stress syndrome Associated with

Reported in Disbiome.

Preliminary

Neuromyelitis optica Associated with

Reported in Disbiome.

Preliminary

Atrophic gastritis Associated with

Reported in Disbiome.

Preliminary

Chronic stress Associated with

Reported in Disbiome.

Preliminary

Stevens-Johnson syndrome Associated with

Reported in Disbiome.

Preliminary

Human end-stage renal disease Associated with

Reported in Disbiome.

Preliminary

Covid-19 Associated with

Reported in Disbiome.

Preliminary

Ischemic stroke Associated with

Reported in Disbiome.

Preliminary

Frailty Associated with

Reported in Disbiome.

Preliminary

Crohn Disease Associated with

Reported in Peryton.

Preliminary

Colorectal Neoplasms Associated with

Reported in Peryton.

Preliminary

Parkinson Disease Associated with

Reported in Peryton.

Preliminary

Thrombosis Associated with

Reported in Peryton.

Preliminary

Diarrhea Associated with

Reported in Peryton.

Preliminary

Liver Neoplasms Associated with

Reported in Peryton.

Preliminary

Stomach Neoplasms Associated with

Reported in Peryton.

Preliminary

Thyroid Neoplasms Associated with

Reported in Peryton.

Preliminary

Uterine Cervical Neoplasms Associated with

Reported in Peryton.

Preliminary

Pharyngeal Neoplasms Associated with

Reported in Peryton.

Preliminary

Esophageal Neoplasms Associated with

Reported in Peryton.

Preliminary

What shifts it

Dietary fibre Raises it

Nutrient

Moderate evidence Well-established

Helps make

Short-chain fatty acidsneurotransmitter

The dominant chemical channel from gut to brain. Made when fibre-fermenters break down fibre, SCFAs feed the gut lining, calm microglia, tune the blood–brain barrier, and signal along the vagus nerve. Not a neurotransmitter in the textbook sense — but arguably the microbiome’s most important neuroactive output.

‹ All organisms